The MilliSolve System is designed to filter HPLC buffers and solvents under vacuum. The system uses 0.45 µm membrane filters to remove contaminants that reduce column life. Vacuum filtration also removes a significant proportion of dissolved gases from buffers, reducing the risk of bubbles that can interact with HPLC equipment. In addition, with automatic and continuous filtration, there is no need to add liquid to the funnel during the filtration process.